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Medicines that inhibit CYP2D6 action, for example paroxetine and quinidine, may perhaps induce lowered clearance of oxycodone which could lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.In the same way to most other opioids, oxycodone inc